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Publications


Original Articles: 2000 - Present
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Donnai-Barrow syndrome (DBS/FOAR) in a child with a homozygous LRP2 mutation due to complete chromosome 2 paternal isodisomy.
  • Kantarci S, Ragge NK, Thomas NS, Robinson DO, Noonan KM, Russell MK, Donnai D, Raymond FL, Walsh CA, Donahoe PK, Pober BR.
  • Am J Med Genet A. 2008 Jun 13
  • Article

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Consistent chromosome abnormalities identify novel polymicrogyria loci in 1p36.3, 2p16.1-p23.1, 4q21.21-q22.1, 6q26-q27, and 21q2.

  • Dobyns WB, Mirzaa G, Christian SL, Petras K, Roseberry J, Clark GD, Curry CJ, McDonald-McGinn D, Medne L, Zackai E, Parsons J, Zand DJ, Hisama FM, Walsh CA, Leventer RJ, Martin CL, Gajecka M, Shaffer LG.
  • Am J Med Genet A. 2008 Jun 5
  • Article

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GPR56 regulates pial basement membrane integrity and cortical lamination.

  • Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X.
  • J Neurosci. 2008 May 28
  • Article

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A novel form of lethal microcephaly with simplified gyral pattern and brain stem hypoplasia.

  • Rajab A, Manzini MC, Mochida GH, Walsh CA, Ross ME. Am J Med Genet A. 2007 Dec 1;143(23):2761-7.
  • Article

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A 2-Mb critical region implicated in the microcephaly associated with terminal 1q deletion syndrome.

  • Hill AD, Chang BS, Hill RS, Garraway LA, Bodell A, Sellers WR, Walsh CA. Am J Med Genet A. 2007 Aug 1;143(15):1692-8.
  • Article

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A structural basis for reading fluency: white matter defects in a genetic brain malformation.

  • Chang BS, Katzir T, Liu T, Corriveau K, Barzillai M, Apse KA, Bodell A, Hackney D, Alsop D, Wong S, Walsh CA.
  • Neurology. 2007 Dec 4;69(23):2146-54.
  • Article

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Doublecortin is expressed in articular chondrocytes.

  • Zhang Y, Ryan JA, Di Cesare PE, Liu J, Walsh CA, You Z.
  • Biochem Biophys Res Commun. 2007 Nov 23;363(3):694-700
  • Article

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Periventricular heterotopia with complete agenesis of the corpus callosum : a case report.

  • Neal J, Raju GP, Bodell A, Apse K, Walsh CA, Sheen VL.
  • J Neurol. 2006 Oct;253(10):1358-9
  • Article

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Disease-associated mutations affect GPR56 protein trafficking and cell surface expression.

  • Jin Z, Tietjen I, Bu L, Liu-Yesucevitz L, Gaur SK, Walsh CA, Piao X.
  • Hum Mol Genet. 2007 Aug 15;16(16):1972-85
  • Article

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A Comparative Proteomic Analysis of Human and Rat Embryonic Cerebrospinal Fluid.

  • Zappaterra MD, Lisgo SN, Lindsay S, Gygi SP, Walsh CA, Ballif BA.
  • J Proteome Res. 2007 Sep 7;6(9):3537-3548.
  • Article

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Comprehensive EMX2 genotyping of a large schizencephaly case series.

  • Tietjen I, Bodell A, Apse K, Mendonza AM, Chang BS, Shaw GM, Barkovich AJ, Lammer EJ, Walsh CA
  • Am J Med Genet A. 2007 Jun 15; 143 (12) : 1313-6
  • Article

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Both doublecortin and doublecortin-like kinase play a role in cortical interneuron migration.

  • Friocourt G, Liu JS, Antypa M, Rakic S, Walsh CA, Parnavelas JG
  • J Neuroscie. 2007 Apr 4; 27 (14): 3875-83
  • Article
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Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
  • Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CA.
  • Proc Natl Acad Sci U S A. 2006 Dec 26; 103 (52): 19836-41
  • Article
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Brain Evolution and Uniqueness in the Human Genome.
  • Amadio JP, Walsh CA.
  • Cell. 2006 Sep 12; 126(6): 1033-1035
  • Article
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Deletion of chromosome 1p36 is associated with periventricular nodular heterotopia.
  • Neal J, Apse K, Sahin M, Walsh CA, Sheen VL.
  • Am J Med Genet A. 2006 Jul 11; [Epub ahead of print] No abstract available.
  • PMID: 16835933 [PubMed - as supplied by publisher]
  • Article
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Molecular approaches to brain asymmetry and handedness.
  • Sun T, Walsh CA.
  • Nat Rev Neurosci. 2006 Aug;7(8):655-62.
  • PMID: 16858393 [PubMed - in process]
  • Article
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An autosomal recessive form of spastic cerebral palsy (CP) with microcephaly and mental retardation.
  • Rajab A, Yoo SY, Abdulgalil A, Kathiri S, Ahmed R, Mochida GH, Bodell A, Barkovich AJ, Walsh CA.Am J Med Genet A. 2006 Jun 7;140A(14):1504-1510
  • Article
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Periventricular nodular heterotopia and Williams syndrome.
  • Ferland RJ, Gaitanis JN, Apse K, Tantravahi U, Walsh CA, Sheen VL.
  • Am J Med Genet A. 2006 May 11;140A(12):1305-1311
  • Article
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Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations.
  • Parrini E, Ramazzotti A, Dobyns WB, Mei D, Moro F, Veggiotti P, Marini C, Brilstra EH, Bernardina BD, Goodwin L, Bodell A, Jones MC, Nangeroni M, Palmeri S, Said E, Sander JW, Striano P, Takahashi Y, Van Maldergem L, Leonardi G, Wright M, Walsh CA, Guerrini R.
  • Brain. 2006 May 9
  • Article
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Impaired proliferation and migration in human Miller-Dieker neural precursors.
  • Sheen VL, Ferland RJ, Harney M, Hill RS, Neal J, Banham AH, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA.
  • Ann Neurol. 2006 Apr 26
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Cerebellar ataxia with progressive improvement.
  • Tsao JW, Neal J, Apse K, Stephan MJ, Dobyns WB, Hill RS, Walsh CA, Sheen VL.
  • Arch Neurol. 2006 Apr;63(4):594-7.
  • Article
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Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression.
  • Olson EC, Kim S, Walsh CA.
  • J Neurosci. 2006 Feb 8;26(6):1767-75.
  • Article
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Neocortical neuronal arrangement in Miller Dieker syndrome.
  • Sheen VL, Ferland RJ, Neal J, Harney M, Hill RS, Banham A, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA.
  • Acta Neuropathol (Berl). 2006 Feb 3;1-8
  • Article
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A familial syndrome of unilateral polymicrogyria affecting the right hemisphere.
  • Chang BS, Apse KA, Caraballo R, Cross JH, Mclellan A, Jacobson RD, Valente KD, Barkovich AJ, Walsh CA.
  • Neurology. 2006 Jan 10;66(1):133-5.
  • Article
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Genetic Interactions between Doublecortin and Doublecortin-like Kinase in Neuronal Migration and Axon Outgrowth.
  • Deuel TA, Liu JS, Corbo JC, Yoo SY, Rorke-Adams LB, Walsh CA.
  • Neuron. 2006 Jan 5;49(1):41-53.
  • Article
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Periventricular heterotopia: new insights into ehlers-danlos syndrome
  • Sheen VL, Walsh CA.
  • Clin Med Res. 2005 Nov;3(4):229-33.
  • Article
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Genotype-phenotype analysis of human frontoparietal polymicrogyria
syndromes.
  • Piao X, Chang BS, Bodell A, Woods K, Benzeev B, Topcu M, Guerrini R,
    Goldberg-Stern H, Sztriha L, Dobyns WB, Barkovich AJ, Walsh CA.
  • Ann Neurol. 2005 Oct 20;58(5):680-687
  • Article
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ASPM mutations identified in patients with primary microcephaly and seizures.
  • Shen J, Eyaid W, Mochida GH, Al-Moayyad F, Bodell A, Woods CG, Walsh CA.
  • J Med Genet. 2005 Sep;42(9):725-9.
  • Article
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Molecular insights into human brain evolution.
  • Hill RS, Walsh CA.
  • Nature. 2005 Sep 1;437(7055):64-7.
  • Article
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Characterization of Rho-GDIgamma and Rho-GDIalpha mRNA in the developing and mature brain with an analysis of mice with targeted deletions of Rho-GDIgamma.
  • Ferland RJ, Li X, Buhlmann JE, Bu X, Walsh CA, Lim B.
  • Brain Res. 2005 Aug 23;1054(1):9-21.
  • Article
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The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive nonsyndromic mental retardation.
  • Basel-Vanagaite L, Attia R, Yahav M, Ferland RJ, Anteki L, Walsh CA, Olender T, Straussberg R, Magal N, Taub E, Drasinover V, Alkelai A, Bercovich D, Rechavi G, Simon AJ, Shohat M.
  • J Med Genet. 2005 Jul 20
  • Article
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The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.
  • Kouprina N, Pavlicek A, Collins NK, Nakano M, Noskov VN, Ohzeki J, Mochida GH, Risinger JI, Goldsmith P, Gunsior M, Solomon G, Gersch W, Kim JH, Barrett JC, Walsh CA, Jurka J, Masumoto H, Larionov V.
  • Hum Mol Genet. 2005 Aug 1;14(15):2155-65.
  • Article
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Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway.
  • Soukoulis V, Reddy S, Pooley RD, Feng Y, Walsh CA, Bader DM.
  • Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8549-54
  • Article
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Early Asymmetry of Gene Transcription Between Embryonic Human Left and Right Cerebral Cortex.
  • Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh CA.
  • Science. 2005 May 12 (Epub ahead of print).
  • Article
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EMX2-independent familial schizencephaly: Clinical and genetic analyses.
  • Tietjen I, Erdogan F, Currier S, Apse K, Chang BS, Hill RS, Lee CK, Walsh CA.
  • Am J Med Genet A. 2005 May 10;135A(2):166-170
  • Article
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Targeted disruption of tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice.
  • Shen J, Walsh CA.
  • Mol Cell Biol. 2005 May;25(9):3639-47.
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A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size.
  • Bond J, Roberts E, Springell K, Lizarraga S, Scott S, Higgins J, Hampshire DJ, Morrison EE, Leal GF, Silva EO, Costa SM, Baralle D, Raponi M, Karbani G, Rashid Y, Jafri H, Bennett C, Corry P, Walsh CA, Woods CG.
  • Nat Genet. 2005 Apr;37(4):353-5. Epub 2005 Mar 27.
  • Article
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Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia.
  • Chang BS, Ly J, Appignani B, Bodell A, Apse KA, Ravenscroft RS, Sheen VL, Doherty MJ, Hackney DB, O'Connor M, Galaburda AM, Walsh CA.
  • Neurology. 2005 Mar 8;64(5):799-803.
  • Article
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Mutations in POMT1 are found in a minority of patients with Walker-Warburg syndrome.
  • Currier SC, Lee CK, Chang BS, Bodell AL, Pai GS, Job L, Lagae LG, Al-Gazali LI, Eyaid WM, Enns G, Dobyns WB, Walsh CA.
  • Am J Med Genet A. 2005 Jan 6;133A(1):53-57
  • Article
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Filamin A mutations cause periventricular heterotopia with Ehlers-Danlos syndrome.
  • Sheen VL, Jansen A, Chen MH, Parrini E, Morgan T, Ravenscroft R, Ganesh V, Underwood T, Wiley J, Leventer R, Vaid RR, Ruiz DE, Hutchins GM, Menasha J, Willner J, Geng Y, Gripp KW, Nicholson L, Berry-Kravis E, Bodell A, Apse K, Hill RS, Dubeau F, Andermann F, Barkovich J, Andermann E, Shugart YY, Thomas P, Viri M, Veggiotti P, Robertson S, Guerrini R, Walsh CA.
  • Neurology. 2005 Jan 25;64(2):254-62
  • Article
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Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1{alpha}/CXC chemokine receptor 4 pathway.
  • Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng YD, Frenkel D, Li J, Sidman RL, Walsh CA, Snyder EY, Khoury SJ.
  • Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18117-18122.
  • Article
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The many faces of filamin: a versatile molecular scaffold for cell motility and signalling.
  • Feng Y, Walsh CA.
  • Nat Cell Biol. 2004 Nov;6(11):1034-8.
  • Article
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Mitotic spindle regulation by Nde1 controls cerebral cortical size.
  • Feng Y, Walsh CA.
  • Neuron. 2004 Oct 14;44(2):279-93.
  • Article
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Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex.
  • Nieto M, Monuki ES, Tang H, Imitola J, Haubst N, Khoury SJ, Cunningham J, Gotz M, Walsh CA.
  • J Comp Neurol. 2004 Nov 8;479(2):168-80.
  • Article
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Genetics of disorders of cortical development.
  • Gaitanis JN, Walsh CA.
  • Neuroimaging Clin N Am. 2004 May;14(2):219-29, viii. Review.
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Abnormal cerebellar development and axonal decussation due to mutations in
AHI1 in Joubert syndrome.
  • Ferland RJ, Eyaid W, Collura RV, Tully LD, Hill RS, Al-Nouri D, Al-Rumayyan A, Topcu M, Gascon G, Bodell A, Shugart YY, Ruvolo M, Walsh CA.
  • Nature Genetics. 2004 Aug 22 Advanced Online Publication.
  • Article
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Bilateral generalized polymicrogyria (BGP): a distinct syndrome of cortical malformation.
  • Chang BS, Piao X, Giannini C, Cascino GD, Scheffer I, Woods CG, Topcu M, Tezcan K, Bodell A, Leventer RJ, Barkovich AJ, Grant PE, Walsh CA.
  • Neurology. 2004 May 25;62(10):1722-8.
  • Article
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Broader geographical spectrum of Cohen syndrome due to COH1 mutations.
  • Mochida GH, Rajab A, Eyaid W, Lu A, Al-Nouri D, Kosaki K, Noruzinia M, Sarda P, Ishihara J, Bodell A, Apse K, Walsh CA.
  • J Med Genet. 2004 Jun;41(6):E87.
  • Article
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Etiological heterogeneity of familial periventricular heterotopia and hydrocephalus.
  • Sheen VL, Basel-Vanagaite L, Goodman JR, Scheffer IE, Bodell A, Ganesh VS, Ravenscroft R, Hill RS, Cherry TJ, Shugart YY, Barkovich J, Straussberg R, Walsh CA.
  • Brain Dev. 2004 Aug;26(5):326-34.
  • Article
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Genetic basis of developmental malformations of the cerebral cortex.
  • Mochida GH, Walsh CA.
  • Arch Neurol. 2004 May;61(5):637-40.
  • Article
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Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior
to Human Brain Expansion
  • Kouprina N, Pavlicek A, Mochida GH, Solomon G, Gersch W, Yoon YH, Collura R, Ruvolo M, Barrett JC, Woods CG, Walsh CA, Jurka J, Larionov V.
  • PLoS Biol. 2004 May;2(5):E126. Epub 2004 Mar.
  • Article
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G protein-coupled receptor-dependent development of human frontal cortex
  • Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Ross ME, Michaud JL, Descarie JC, Barkovich AJ, Walsh CA.
  • Science. 2004 Mar 26; 303(5666):2033-6.
  • Abstract
  • Article
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The hyh Mutation Uncovers Roles for αSnap in Apical Protein Localization and Control of Neural Cell Fate
  • Chae TH, Kim S, Marz KE, Hanson PI, Walsh CA.
  • Nature Genetics. 2004 Mar;36(3):264-70.
  • Article
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Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex.
  • Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA.
  • Nature Genetics. 2004 36(1):69-76.
  • Article
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Mapping form and function in the human brain: the emerging field of functional neuroimaging in cortical malformations.
  • Chang BS, Walsh CA.
  • Epilepsy Behav. 2003 4(6):618-25.
  • Article
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Protein-truncating mutations in ASPM cause variable reduction in brain size.
  • Bond J, Scott S, Hampshire DJ, Springell K, Corry P, Abramowicz MJ, Mochida GH, Hennekam RC, Maher ER, Fryns JP, Alswaid A, Jafri H, Rashid Y, Mubaidin A, Walsh CA, Roberts E, Woods CG.
  • Am J Hum Genet. 2003 Nov;73(6):1170-7.
  • Article
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A novel form of pontocerebellar hypoplasia maps to chromosome 7q11-21.
  • Rajab A, Mochida GH, Hill A, Ganesh V, Bodell A, Riaz A, Grant PE, Shugart YY, Walsh CA.
  • Neurology. 2003 60:1664-7.
  • Article
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Characterization of Foxp2 and Fox1 mRNA and protein in the developing and mature brain.
  • Ferland RJ, Cherry TJ, Preware PO, Morrisey EE, Walsh CA.
  • J. Comp. Neurol. 2003 460:266-279.
  • Article
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Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16.
  • Chang BS, Piao X, Bodell A, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Grant PE, Barkovich AJ, Walsh CA.
  • Ann. Neurol. 2003 53:596-606.
  • Article
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Cryptic t(1;12) (q44;p13.3) translocation in a previously described syndrome with polymicrogyria, segregating as an apparently X-linked trait.
  • Zollino M, Colosimo C, Zuffardi O, Rossi E, Tosolini A, Walsh CA, Neri G.
  • Am. J. Med. Genet. 2003 117A:65-71.
  • Article
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The DCX-domain tandems of Doublecortin and doublecortin-like kinase.
  • Kim MH, Cierpicki T, Derewenda U, Krowarsch D, Feng Y, Devedjiev Y, Dauter Z, Walsh CA, Otlewski J, Bushweller JH, Derewenda ZS.
  • Nature Struct. Biol. 2003 10:324-33.
  • Article
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Markers of cellular proliferation are expressed in cortical tubers.
  • Lee A, Maldonado M, Baybis M, Walsh CA, Scheithauer B, Yeung R, Parent J, Weiner HL, Crino PB.
  • Ann. Neurology. 2003 53:668-73.
  • Article
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Increased neuronal production, enlarged forebrains, and cytoarchitectural distortions in Beta Catenin transgenic mice.
  • Chenn A, Walsh CA.
  • Cerebral Cortex 2003 13: 599-606
  • Article
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Reelin is expressed in the olfactory system but is not a guidance cue for universal axons.
  • Teillon S, Yiu G, Walsh CA.
  • Dev Brain Res 2003 140: 303-307
  • Article
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Periventricular heterotopia associated with chromosome 5p anomalies.
  • Sheen V, Wheless J, Bodell A, Bravermann E, Cotter P, Rauen K, Glenn O, Weisiger K, Packman S, Walsh C, Sherr E.
  • Neurology 2003 60: 1033-1036
  • Article
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Autosomal recessive form of periventricular heterotopia.
  • Sheen V, Topcu M, Berkovic S, Yalnizoglu D, Blatt I, Bodell A, Hill R, Ganesh V, Cherry T, Shugart Y, Walsh C.
  • Neurology 2003 60: 1108-1112
  • Article
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Genetic Disorders of Human Cerebral Cortical Development.
  • Walsh CA.
  • Advances in Clinical Neurosciences. 2002; 12: 515-527.
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Smooth, rough and upside down neocortical development.
  • Olson E and Walsh CA.
  • Current Opinion in Genetics and Development 2002:12:320-327.
  • Article
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Filamin A (filamin1) and filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.
  • Sheen V, Feng Y, Graham D, Takafuta T, Shapiro SS & Walsh C.
  • Human Molecular Genetics. 2002 11:2845-2854.
  • Article
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ASPM is a major determinant of cerebral cortical size.
  • Bond J, Roberts E, Mochida GH, Hampshire D, Scott S, Askham JM, Springell K, Mahadevan M, Crow Y, Markham AF, Walsh CA, Woods CG.
  • Nature Genetics. 2002 32:316-320.
  • Article
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Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome.
  • Valero de Bernabe DB, Currier S, Steinbrecher A, Celli J, van Beusekom E, van der Zwaag, Kayserili H, Merlini L, Chitayat D, Dobyns WB, Cormand B, Lehesjoki AE, Cruces J, Voit T, Walsh CA, van Bokhoven H, Brunner HG.
  • Am. J. Human Genetics. 2002 71:1033-43.
  • Article
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Doublecortin is required in mice for lamination of the hippocampus but not the neocortex.
  • Corbo JC, Deuel TA, Long JM, LaPorte P, Tsai E, Wynshaw-Boris T, Walsh CA.
  • J. Neurosci. 2002 22:7548-57.
  • Article
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Regulation of cerebral cortical size by control of cell cycle exit in neural precursors.
  • Chenn A, and Walsh CA.
  • Science. 2002 297:365-369
  • Article
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Bilateral periventricular nodular heterotopia due to filamin 1 gene mutation: widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortex.
  • Kakita A, Hayashi S, Moro F, Guerrini R, Ozawa T, Ono K, Kameyama S, Walsh CA, Takahashi H.
  • Acta Neuropathol. 2002 104:649-57.
  • Article
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Evidence of common progenitors and patterns of dispersion in rat striatum and cerebral cortex.
  • Reid CB, Walsh CA.
  • The Journal of Neuroscience. 2002 22:4002-4014.
  • Article
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An Autosomal recessive form of bilateral frontoparietal polymicrogyria (BFPP) maps to chromosome 16 q12.2-21.
  • Piao X, Basel-Vanagaite L, Straussberg R, Grant PE, Pugh EW, Doheny K, Doan B, Hong SE, Shugart YY, Walsh CA.
  • Am. J. Human Genetics. 2002 70:1028-1033.
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Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7.
  • Chae TH, Allen KM, Davisson MT, Sweet, HO, Walsh CA.
  • Mammalian Genome. 2002 13:239-44.
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Mechanisms of cerebral cortical patterning in mice and humans.
  • Monuki ES and Walsh CA.
  • Nature Neuroscience. 2001:4:1199-1206.
  • Article
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Protein-protein interactions, cytoskeletal regulation, and neuronal migration.
  • Feng Y, and Walsh CA.
  • Nature Neuroscience Reviews. 2001:408-416.
  • Article
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Molecular genetics of human microcephaly.
  • Mochida GH, Walsh CA.
  • Current Opinion in Neurology. 2001;14:151-156.
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Neuroscience in the post-genome era: an overview.
  • Walsh CA.
  • Trends in Neurosciences. 2001:363-364.
  • Article
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Human brain malformations and their lessons for neuronal migration. Ann. Rev.
  • Ross, ME and Walsh, CA.
  • Neurosci. 2001;24:1041-70.
  • Article
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Telencephalic Neural precursors appear to be restricted to regional and glial fates before the onset of neurogenesis.
  • McCarthy M, Turnbull DH, Walsh CA, Fishell G.
  • Neuroscience. 2001 21: 6772-6781.
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Callosal agenesis with cyst A better understanding and new classification.
  • Barkovich AJ, Simon EM, Walsh CA.
  • Neurology. 2001 56:220-227.
  • Article
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Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopias in males as well as in females
  • Sheen VL, Dixon P, Hong SE, Fox JW, Kinton L, Sisodiya SM, Duncan JS, Seni HM, Scheffer IE, Schachter SC, Wilner A, Henchy R, Crino P, Kamuro K, DiMario F, Berg M, Kuzniecky R, Cole A, Bromfield E, Biber M, Schomer D, Wheless J, Silver K, Mochida G, Berkovic SF, Andermann E, Dobyns WB, Wood NW & Walsh CA.
  • Human Molecular Genetics. 2001 10: 1775-1783.
  • Article
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Patterning of the dorsal telencephalon and cerebral cortex by a roofplate-Lhx2 pathway
  • Monuki ES, Porter FD, and Walsh CA
  • Neuron. 2001 Nov 20;32(4):591-604.
  • Article
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LIS1 Regulates CNS Lamination by Interacting with mNudE, a Central Component of the Centrosome
  • Feng YF, Olson EC, Flanagan L, Stukenberg T, Kirschner MC, Walsh CA.
  • Neuron. 2000 28:665-679
  • Article
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A mapping label required for normal scale of body representation in the cortex
  • Vanderhaeghen P, Lu Q, Prakash N, Frisen J, Walsh CA, Frostig RD, Flanagan JG
  • Nature Neurosci. 2000 3:358-365.
  • [PubMed Link]
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Periventricular nodular heterotopia in patients with filamin-1 gene mutations: Neuroimaging findings
  • Poussaint TY, Fox JW, Dobyns WB, Radtke R, Scheffer IE, Berkovic SF, Barnes PD, Huttenlocher PR, Walsh CA.
  • Pediatric Radiology. 2000 30: 748-755.
  • Article
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Somatic and germline mosaic mutations in the doublecortin gene associated with variable phenotypes
  • Gleeson, JG, Minnerath S, Kuzniecky RI, Dobyns WB, Ross ME, Young IA, Walsh CA.
  • American Journal of Human Genetics. 2000 67: 574-581.
  • Article
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Patient mutations in Doublecortin define a repeated microtubule-binding domain
  • Taylor KR, Holzer A, Walsh CA, Bazan JF, Gleeson JG.
  • Journal of Biological Chemistry. 2000 275: 34442-34450.
  • Article
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Autosomal recessive lissencephaly with cerebellar hypoplasia (LCH) is associated with human reelin gene mutations
  • Hong SE, Huang DT, Shugart YY, Al Shahwan S, Grant PE, Hourihane JOB, Martin NDT, Walsh CA.
  • Nature Genetics. 2000 26: 93-96.
  • Article
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Reelin binds a3&Mac254;1 integrin and inhibits neuronal migration
  • Dulabon L, Olson EC, Gordy M, Eisenhuth S, McGrath B, Walsh CA, Kreidberg JA, Anton ES.
  • Neuron. 2000 27: 33-44
  • Article
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DCAMKL1 encodes a protein kinase with homology to Doublecortin that regulates microtubule polymerization in a kinase-independent fashion
  • Lin PT, Glesson JG, Corbo JC, Flanagan L, Walsh CA
  • J. Neurosci. 2000 20: 9152-9161
  • Article
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Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation
  • Bienvenu T, des Portes V, McDonell N, Carrie A, Zemni R, Couvert P, Ropers HH, Moraine C, van Bokhoven H, Fryns J P ,Allen K, Walsh C, Boue A, Kahn A, Chelly J, Beldjord, CA
  • Am J Med Gene. 2000 93, 294-8.
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Original Articles: 1996 - 2000

Genetic and neuroradiological heterogeneity of double cortex syndrome
  • Gleeson JG, Luo RF, Grant PE, Guerrini R, Huttenlocher PR, Berg MJ, Ricci S, Cusmai R, Wheless JW, Berkovic S, Scheffer I, Dobyns WB, Walsh CA
  • Annals of Neurology 2000 Feb;47(2):265-9
  • [PubMed Link]
Studies of the candidate genes in X-linked congenital cerebellar hypoplasia

  • Illarioshkin SN, Allen KM, Gleeson JG, Tsuji S, Ikeuchi T, Markova ED, Walsh CA, Ivanova-Smolenskaya IA
  • Journal of Neurology. 1999 Dec;246(12):1177-80
  • [PubMed Link]
Differences in gyral pattern distinguish chromosome 17-linked lissencephaly and X-linked lissencephaly

  • Dobyns WB, Truwit CL, Ross ME, Matsumoto N, Pilz DT, Ledbetter DH, Gleeson JG, Walsh CA, and Barkovich AJ
  • Neurology. 1999 Jul 22;53(2):270-7
  • [PubMed Link]
Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons

  • Gleeson JG, Lin PT, Flanagan LA, Walsh CA
  • Neuron. 1999 Jun;23(2):257-71
  • [Abstract] | [PubMed Link]
Coexistence of widespread clones and large radial clonal patterns in early ferret cortex

  • Ware ML, Tavasoie S, Reid CB, Walsh CA
  • Cerebral Cortex. 1999 Sep;9(6):636-45
  • [PubMed Link]
Characterization of mutations in the gene doublecortin in patients with double cortex syndrome

  • Gleeson JG, Minnerath SR, Allen KM, Fox JW, Hong SE, Berg MJ, Kuzniecky R, Reitnauer PJ, Borgatti R, Mira AP, Guerrini R, Holmes GL, Rooney CM, Berkovic S, Scheffer I, Cooper EC, Leroy R, Andermann E, Wheless JW, Dobyns WB, Ross ME, Walsh CA
  • Annals of Neurology. 1999 Feb;45(2):146-53
  • [PubMed Link]
Clonal mixing, clonal restriction, and specification of cell types in the developing rat olfactory bulb

  • Reid CB, Liang I, and Walsh, CA
  • Journal of Comparative Neurology. 1999 Jan 5;403(1):106-18
  • [PubMed Link]
Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia

  • Fox JW, Lamperti ED, Eksioglu YZ, Hong SE, Feng Y, Graham DA, Scheffer IE, Dobyns WB, Hirsch BA, Radtke RA, Berkovic SF, Huttenlocher PR, Walsh CA
  • Neuron. 1998 21(6): 1315-1325
  • [Abstract] | [PubMed Link] | [Full Text]
PAK3 mutation in nonsyndromic X-linked mental retardation

  • Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA
  • Nature Genetics. 1998 20(1): 25-30
  • [Abstract] | [PubMed Link]
LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation

  • Pilz DT, Matsumoto N, Minnerath S, Mills P, Gleeson JG, Allen KM, Walsh CA, Barkovich AJ, Dobyns WB, Ledbetter DH, Ross ME
  • Human Molecular Genetics. 1998 Dec;7(13):2029-37
  • [PubMed Link]
A YAC contig in Xq23, from DXS287 to DXS2088, spanning the critical region for double cortex/X-linked lissencephaly (DC/XLIS)

  • Allen KM, Gleeson JG, Shoup SM, Walsh CA
  • Genomics. 1998 Sep 1;52(2):214-8
  • [PubMed Link]
Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein

  • Gleeson JG, Allen KM, Fox JW, Lamperti ED, Berkovic S, Scheffer I, Cooper EC, Dobyns WB, Minnerath SR, Ross ME, Walsh CA
  • Cell. 1998 92(1): 63-72
  • [Abstract] | [PubMed Link] [Article]
X-linked female band heterotopia-male lissencephaly syndrome

  • Berg MJ, Schifitto G, Powers JM, Martinez-Capolino C, Fong CT, Myers GJ, Epstein LG, Walsh CA
  • Neurology. 1998 Apr;50(4):1143-6
  • [PubMed Link]
Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse

  • Ware ML, Fox JW, Gonzalez JL, Davis NM, Lambert de Rouvroit C, Russo CJ, Chua SC Jr, Goffinet AM, Walsh CA
  • Neuron. 1997 Aug;19(2):239-49
  • [Abstract] | [PubMed Link]
Birthdate and cell marker analysis of scrambler: a novel mutation affecting cortical development with a reeler-like phenotype

  • Gonzalez JL, Russo CJ, Goldowitz D, Sweet HO, Davisson MT, Walsh CA
  • Journal of Neuroscience. 1997 Dec 1;17(23):9204-11
  • [PubMed Link]
Clonal dispersion and evidence for asymmetric cell division in ferret cortex

  • Reid CB, Tavazoie SF, Walsh CA
  • Development. 1997 Jun;124(12):2441-50
  • [Abstract] | [PubMed Link]
Linkage and physical mapping of X-linked lissencephaly/SBH (XLIS): a gene causing neuronal migration defects in human brain

  • Ross ME, Allen KM, Srivastava AK, Featherstone T, Gleeson JG, Hirsch B, Harding BN, Andermann E, Abdullah R, Berg M, Czapansky-Bielman D, Flanders DJ, Guerrini R, Motte J, Mira AP, Scheffer I, Berkovic S, Scaravilli F, King RA, Ledbetter DH, Schlessinger D, Dobyns WB, Walsh CA
  • Human Molecular Genetics. 1997 Apr;6(4):555-62
  • [PubMed Link]
Periventricular heterotopia: an X-linked dominant epilepsy locus causing aberrant cerebral cortical development

  • Eksioglu YZ, Scheffer IE, Cardenas P, Knoll J, DiMario F, Ramsby G, Berg M, Kamuro K, Berkovic SF, Duyk GM, Parisi J, Huttenlocher PR, Walsh CA
  • Neuron. 1996 Jan;16(1):77-87
  • [Abstract] | [PubMed Link]
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Original Articles: 1991 - 1995

Systematic widespread clonal organization in cerebral cortex
  • Reid CB, Liang I, Walsh CA
  • Neuron. 1995 Aug;15(2):299-310
  • [PubMed Link]
Clonal dispersion in proliferative layers of developing cerebral cortex
Walsh C, Cepko CL

Widespread dispersion of neuronal clones across functional regions of the cerebral cortex

  • Walsh C, Cepko CL
  • Science. 1992 Jan 24;255(5043):434-40
  • [PubMed Link]
Multipotent neural cell lines can engraft and participate in development of mouse cerebellum

  • Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartwieg EA, Cepko CL
  • Cell. 1992 Jan 10;68(1):33-51
  • [PubMed Link]
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Original Articles: Pre-1991

Clonally related cortical cells show several migration patterns
  • Walsh C, Cepko CL
  • Science. 1988 Sep 9;241(4871):1342-5
  • [PubMed Link]
Early uncrossed component of the developing optic nerve with a short extracerebral course: a light and electron microscopic study of fetal ferrets

  • Guillery RW, Walsh C
  • Journal of Comparative Neurology. 1987 Nov 8;265(2):218-23
  • [PubMed Link]
Changing glial organization relates to changing fiber order in the developing optic nerve of ferrets

  • Guillery RW, Walsh C
  • Journal of Comparative Neurology. 1987 Nov 8;265(2):203-17
  • [PubMed Link]
Age-related fiber order in the ferret's optic nerve and optic chiasm

  • Walsh C
  • Journal of Neuroscience. 1986 Jun;6(6):1635-42
  • [PubMed Link]
Age-related fiber order in the optic tract of the ferret

  • Walsh C, Guillery RW

  • Journal of Neuroscience. 1985 Nov;5(11):3061-9

  • [PubMed Link]
The topography of ganglion cell production in the cat's retina

  • Walsh C, Polley EH
  • Journal of Neuroscience. 1985 Mar;5(3):741-50
  • [PubMed Link]
A technique for flat embedding and en face sectioning of the mammalian retina for autoradiography

  • Polley EH, Walsh C
  • Journal of Neuroscience Methods. 1984 Nov;12(1):57-64
  • [PubMed Link]
Generation of cat retinal ganglion cells in relation to central pathways

  • Walsh C, Polley EH, Hickey TL, Guillery RW
  • Nature. 1983 Apr 14;302(5909):611-4
  • [PubMed Link]
Relationship of molecular structure to in vivo distribution of carbon-11-labeled compounds. VI. Carbon-11-labeled aliphatic diamines

  • Winstead MB, Dischino DD, Munder NA, Walsh C, Winchell HS
  • European Journal of Nuclear Medicine. 1980 Apr;5(2):165-9

  • [PubMed Link]

Testosterone stimulates ultrasound production by male hamsters

  • Floody OR, Walsh C, Flanagan MT
  • Hormones and Behavior. 1979 Apr;12(2):164-71
  • [PubMed Link]
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Reviews, Chapters, Editorials

Genetics of disorders of cortical development.
  • Gaitanis JN, Walsh CA.
  • Neuroimaging Clin N Am. 2004 May;14(2):219-29.
Genetic malformations of the human cerebral cortex.

  • Sabry M, Mochida G, Walsh CA.
  • In Principles and Practice of Medical Genetics. B. Korf, ed. 2002;112:3012-3035.
Human brain malformations and their lessons for neuronal migration.

  • Ross, ME and Walsh, CA.
  • Ann. Rev. Neurosci. 2001;24:1041-70.
Neuroscience in the post-genome era: an overview.

  • Walsh CA.
  • Trends in Neurosciences. 2001:363-364.
Protein-protein interactions, cytoskeletal regulation, and neuronal migration

  • Feng Y, and Walsh CA.
  • Nature Neuroscience Reviews. 2001:408-416.
Molecular genetics of human microcephaly

  • Mochida GH, Walsh CA
  • Current Opinion in Neurology. 2001;14:151-156.
Proto-mapping the areas of cerebral cortex: transcription factors make the grade

  • Monuki ES and Walsh CA
  • Nature Neuroscience, 2000 640-641.
Neuronal migration disorders in men and mouse: from genetic diseases to developmental mechanisms.

  • Gleeson JG and Walsh CA.
  • Trends in Neurosciences, 2000.
Potential mechanisms of mutations that affect neuronal migration in man and mouse

  • Walsh CA, Goffinet AM
  • Current Opinion in Genetic Development. 2000 Jun;10(3):270-274
  • [PubMed Link]
Perspectives: neurobiology. Cranking it up a notch

  • Chenn A, Walsh CA
  • Science. 1999 Oct 22;286(5440):689-90
  • [PubMed Link]
Periventricular heterotopia and the genetics of neuronal migration in the cerebral cortex

  • Fox JW, Walsh CA
  • American Journal of Human Genetics. 1999 Jul;65(1):19-24
  • [PubMed Link]
Genetic malformations of the human cerebral cortex

Cell lineage and cell migration in the developing cerebral cortex

  • Ware ML and Walsh CA
  • In Cell Fate and Cell Fate Determination. Ed. SA Moody. New York: Academic Press, 1999, 529-547
Early events in the development of the cerebral cortex

  • Walsh CA
  • In Epilepsy: A Comprehensive Textbook, 2nd edition and CD-ROM edition. Ed. Engel J and Pedley TA. New York: Lippincott-Raven Publishers, 1998
Cell lineage analysis in the central nervous system

  • Walsh CA
  • In Encyclopedia of Neuroscience. Berlin: Elsevier Press, 1998
LISsen up!

  • Walsh CA
  • Nature Genetics. 1998 Aug;19(4):307-8
  • [PubMed Link]
New genetic insights into cerebral cortical development

  • Gleeson JG and Walsh CA
  • In Normal and Abnormal Development of the Cerebral Cortex. Ed. A Galaburda and Y Christen. Berlin: Springer-Verlag, 1997, 145-163
Epilepsy Genetics

  • Walsh CA
  • In On the Brain. Winter 1997.
Early events in the development of the cerebral cortex

  • Walsh CA
  • In Epilepsy: A Comprehensive Textbook. Ed. Engel J and Pedley TA. New York: Lippincott-Raven Publishers, 1997, 369-375
X-linked malformations of neuronal migration

  • Dobyns WB, Andermann E, Andermann F, Czapansky-Beilman D, Dubeau F, Dulac O, Guerrini R, Hirsch B, Ledbetter DH, Lee NS, Motte J, Pinard JM, Radtke RA, Ross ME, Tampieri D, Walsh CA, Truwit CL
  • Neurology. 1996 Aug;47(2):331-9
  • [PubMed Link]
Shaking down new epilepsy genes

  • Allen KM, Walsh C
  • Nature Medicine. 1996 May;2(5):516-8
  • [PubMed Link]
Early development of the cerebral cortex

  • Reid CB, Walsh CA
  • Progress in Brain Research. 1996;108:17-30
  • [PubMed Link]
Neural development: identical twins separated at birth?

PCR-based techniques for utilizing retroviruses as cell lineage markers

  • Walsh CA
  • In Methods in Molecular Genetics, Vol. 4: Molecular Virology. Ed. Adolph KW. Orlando, FL: Academic Press, 1995; 7: 280-295
Neuronal identity, neuronal migration, and epileptic disorders of the cerebral cortex

  • Walsh CA
  • In Brain Development and Epilepsy. Ed. Schwartzkroin P et al. New York: Oxford University Press, 1995; pp. 122-143
Cell lineage and regional specification in the mammalian neocortex

  • Walsh CA
  • Perspectives on Developmental Biology. 1993;1(2):75-80
  • [PubMed Link]
Lineage analysis using retrovirus vectors

  • Cepko CL, Ryder EF, Austin CP, Walsh C, Fekete DM
  • Methods in Enzymology. 1993;225:933-60
  • [PubMed Link]
Cell lineage and cell migration in the developing cerebral cortex

  • Walsh C, Cepko CL
  • Experientia. 1990 Sep 15;46(9):940-7
  • [PubMed Link]
The optic nerves, optic chiasm, and optic tracts

  • Walsh CA
  • In Encyclopedia of Neuroscience. Ed. Adelman G. Boston: Birkhauser Boston, 1987: 888-890
Fibre order in the pathways from the eye to the brain

  • Walsh C, Guillery RW
  • Trends in Neurosciences. 1984;7:208-211
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Proceedings of Meetings

Genes that regulate neuronal migration in the cerebral cortex
  • Allen KM, Walsh CA
  • Epilepsy Research. 1999 Sep;36(2-3):143-54
  • [PubMed Link]
Cell lineage and patterns of migration in the developing cortex

  • Walsh C, Reid C
  • Ciba Foundation Symposium. 1995;193:21-40; discussion 59-70
  • [PubMed Link]
Studies of cortical development using retrovirus vectors

  • Cepko CL, Austin CP, Walsh C, Ryder EF, Halliday A, Fields-Berry S
  • Cold Spring Harbor Symposium on Quantitative Biology. 1990;55:265-78
  • [PubMed Link]
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Clinical Communications

Progress in mapping the genes for epilepsy
  • Walsh, CA
  • Journal Watch Neurology. 2000 2:30
Bowl-game pulmonary embolism

  • Walsh C, Lauer MS, Huang PL, Page RL
  • New England Journal of Medicine. 1986 May 15;314(20):1324
  • [PubMed Link]
Original Articles, reviews & other publications are listed in reverse chronological order.

Original Articles:
2000-Present | 1996-2000 | 1991-1995 | Pre-1991 | Reviews, Chapters, Editorials | Proceedings of Meetings | Clinical Communications



PubMed list of articles
by Walshlab