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Research Interests
Our laboratory is interested in cellular and genetic mechanisms of
development of the cerebral cortex, the largest structure of the
mammalian brain. The cortex represents a folded sheet of neurons that
forms a wrapping around the outside of the brain. The cortex is a good
system for studying neuronal development, since there are known
mutations that systematically disrupt its development.
Abnormal development of the
cerebral cortex in humans results in epilepsy, autism, mental
retardation, dyslexia, and other learning disorders, and perhaps some
psychiatric conditions as well. Several projects are directed at trying
to understand the basic biology of the cortex by studying the mutations
that disturb its development.
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